Section III. SPECIFIC REPRODUCTIVE HORMONES
In the previous sections, general concepts related to reproductive hormones
were presented. You were told of the effects, uses, and side effects associated with
these agents. In this section, specific reproductive hormones will be discussed.
8-12. SPECIFIC ESTROGEN AGENTS
a. Conjugated Estrogens (Premarin). Premarin is used in estrogen
replacement therapy. Side effects associated with Premarin are listed in paragraph 8-
5. Provide the patient with a patient package insert (PPI) when dispensing this product.
Premarin is available in tablet, topical cream, vaginal cream, and injectable forms.
b. Chlorotrianisene (Tace). This estrogen is used to prevent postpartum
breast engorgement. The usual dosage of this product is 12 milligrams four times daily
for seven days or 50 milligrams every six hours for six doses. Because of the short
duration of therapy associated with this product, nausea and vomiting are often
associated with its use. Tace also produces side effects such as those listed in
paragraph 5-8 in some patients. When you dispense this product you should inform the
patient that the medication should be taken until it is gone. Furthermore, a PPI should
be provided to the patient when this product is dispensed. Tace is supplied in capsule
c. Ethinyl Estradiol (Estinyl). This estrogen product is used for estrogen
replacement therapy, in the palliative treatment of cancer, and as a contraceptive. For
the side effects associated with this agent, read paragraph 8-5. Provide the patient with
a patient package insert when this product is dispensed. Estinyl is available in tablet
d. Dienestrol. This estrogen product is used in estrogen replacement therapy
and in the treatment of atrophic vaginitis. (Atrophic vaginitis is a condition sometimes
observed in postmenopausal women. Dryness and itchiness of the vagina characterize
it.) This preparation is supplied in the form of a cream. The usual dose of this product
is one applicator full applied vaginally. Since this product is absorbed locally, the side
effects associated with this agent are the same as for the other estrogens. Provide the
patient with a PPI when you dispense this product.