(3) Sodium sulfacetamide (Sulamyd). This agent is an ophthalmic
preparation used for external ocular infections. With the exception of burns, there are
few, if any, adverse reactions; it is available in solution and ointment forms.
(a) This is a topical agent used to prevent colonization of both gram
positive and gram negative organisms in second and third degree burns.
(b) It causes intense pain at the application site, and carbonic
anhydrase is inhibited causing metabolic acidosis.
Silver Sulfadiazine (Silvadene).
(a) This agent is used in the same manner as that described in (4)
above. In addition, it is very effective against yeast organisms.
(b) Adverse reactions to this agent are infrequent and are limited to
localized burning, rash, and itching.
(6) Vaginal products. These products are used in the treatment of vaginal
infections caused by a variety of organisms. They are available either as suppositories
or as creams. The most frequent adverse reaction to these products is localized vaginal
itching. These products are available as AVC or Sultrin.
(a) This class of drugs is not related to sulfonamides, but is often used
in conjunction with them in the treatment of urinary tract infections. They reduce the
pain caused on urination and the itchy feeling associated with the infection.
(b) These compounds are azo dyes, and their use may discolor the
urine or feces.
The most commonly used urinary analgesic is phenazopyridine