Figure 6-2. Effect of divided doses in blood.
Figure 6-3. Effect of sustained-release dosage form in blood.
There are several disadvantages and limitations of this form of dosage.
Sustained-release dosage forms are more expensive to produce. Variation of the size
of the dose for a particular individual is difficult or impractical. Once the medication has
been administered, it cannot be discontinued until its effects have finally ceased. In
addition, some drugs are not suitable for preparation in this form.