Quantcast Cracking of Emulsions - Compounding and Manufacturing

Share on Google+Share on FacebookShare on LinkedInShare on TwitterShare on DiggShare on Stumble Upon
Custom Search
 
  
 
4-7.
CRACKING OF EMULSIONS
a. When an emulsion separates into its separate ingredients (when the oil and
water are clearly separated and will not recombine) the emulsion is said to have
"cracked" or "broken." Do not confuse a "cracked" emulsion with one that has creamed!
Creaming is a natural occurrence with most emulsions and simple shaking will restore
the uniformity of the preparation. However, no amount of shaking will restore the
cracked emulsion to its original state.
b. The most common reason that an emulsion cracks is the addition of too much
or too concentrated alcohol or electrolyte solution. Freezing will also cause an emulsion
to crack.
4-8.
DISPENSING AN EMULSION
a. Container. Emulsions of thick consistency should be dispensed in a
wide-mouthed bottle or jar. The very thin emulsions may be dispensed in ordinary
prescription bottles, if they will not become thicker as the emulsifier hydrates on
standing. Thick emulsions cannot be conveniently poured from narrow-mouthed
bottles. Clear bottles are generally preferred to amber ones, unless their contents are
sensitive to light.
b. Special Instructions. All emulsions are damaged by excessive heat or cold.
Patients should be instructed to store emulsions away from either extreme. Emulsions
for internal use should be stored in the refrigerator, but they should be protected from
freezing. All emulsions should bear the "Shake Well Before Using" label. Those for
external use should be so labeled.
Section II. SUSPENSIONS
4-9.
INTRODUCTION
Both emulsions and suspensions are types of dispersions. Suspensions are
liquid preparations that contain a finely divided dispersed solid. They are quite closely
related to emulsions except that their internal phase is a solid rather than another liquid.
If the particle size is less than 0.1 micrometer, where a micron is a millionth of a meter,
we say that we have a colloid, not a suspension. Suspensions are usually intended for
external use, oral administration, or injection. The tendency of suspensions to settle out
makes them slightly less desirable as a dosage form than solutions; the solid particles
agglomerate and settle to the bottom, leaving the liquid phase supernatant. It is quite
possible to prepare a suspension that will not settle appreciably for several months. In
the pharmacy, this should be the goal for every suspension prepared: to lengthen the
settling time as much as possible. The absolute minimum requirement of settling time is
a rate slow enough to allow the medication to be shaken and a dose to be removed
from the container that will be uniform in content each time.
MD0809
4-6



Medical News
Congenital heart disease specialists develop nonsurgical technique to correct birth defects
A new technique for repairing the most common cardiac birth...
medicalxpress.com
Health Care Funding Changes Impact STI Testing, Study Finds
Universal health coverage and changes in the way Massachusetts funds...
bumc.bu.edu
Preterm children's brains can catch up years later
There's some good news for parents of preterm babies –...
medicalxpress.com
West African airline suspends flights amid Ebola
(AP)—The West African airline that transported a passenger sick with...
medicalxpress.com
Mortality rates increase due to extreme heat and cold
Epidemiological studies have repeatedly shown that death rates rise in...
medicalxpress.com
Women who smoke while pregnant could alter their children's genes
The largest study of its kind has shown that smoking...
medicalxpress.com
Herpes remains active even when no symptoms appear
Scientists investigating the herpes virus have been surprised to find...
medicalxpress.com
Morning Break: Medicare's Sell-By Date Extended
(MedPage Today) -- Health news and commentary from around the...
medpagetoday.com
Determine patient preferences by means of conjoint analysis
The Conjoint Analysis (CA) method is in principle suitable to...
medicalxpress.com
Researchers explore what happens when heart cells fail
Through a grant from the United States-Israel Binational Science Foundation,...
medicalxpress.com
New anesthesia technique helps show cause of obstruction in sleep apnea
A simplified anesthesia procedure may enable more widespread use of...
medicalxpress.com
Key element of CPR missing from guidelines
Removing the head tilt/chin lift component of rescue breaths from...
medicalxpress.com
New research describes trends in substance use among high school athletes
Newly published research from Journal of Child & Adolescent Substance...
medicalxpress.com
What is the plague?
Cases of plague have been reported in the Chinese city...
medicalxpress.com
Low-carb diet recommended for diabetics
A new study involving researchers from the University of Alabama...
medicalxpress.com
It takes more than practice to excel, psychologist reports
Case Western Reserve University's new assistant professor of psychology Brooke...
medicalxpress.com
Collaborative study of uninsured smokers finds benefit from pairing nicotine patches with quitline support
Uninsured smokers who used nicotine replacement therapy (NRT) patches in...
medicalxpress.com
Asbestos Revisited: A New Autoimmune Disease? (CME/CE)
(MedPage Today) -- In the small town of Libby in...
medpagetoday.com
Elderly can get fit in 60 seconds
The health of OAPs can be dramatically improved with high-intensity...
medicalxpress.com
Over 70 and still driving, who do you listen to?
Studies show older drivers self-regulate their actions behind the wheel,...
medicalxpress.com
 


Privacy Statement - Copyright Information. - Contact Us

comments powered by Disqus

Integrated Publishing, Inc.
9438 US Hwy 19N #311 Port Richey, FL 34668

Phone For Parts Inquiries: (727) 755-3260
Google +