EXERCISES, LESSON 4
INSTRUCTIONS: Answer the following items by completing the statement or by writing
the answer in the space provided.
After you have completed all of these items, turn to "Solutions to Exercises" at the
end of the lesson and check your answers with the solutions.
Immunogenetics is the study of processes involved in the i___e response that may
have a g___c basis. These processes include the factors that control the i__e
r____e of the host and the transmission of antigenic s____ties from generation to
The first major area of immunogenetics is concerned with the genetic re__ation
and c___l of the immune system itself. Interruption or alterations of developmental
sequences may lead to i_____cy disorders, auto____e disorders, and perhaps
The second major area of immunogenetics, the one with the broadest application,
is the use of a___dies and s____d immune cells, products of the i___e system, as
probes to detect and characterize various a___ns that may show genetic variation.
The major histocompatibility complex (MHC) is the region of a specific c___me
that controls hi_____y. The term histocompatibility refers to the presence of
certain a____s which mean that the host of an organ or tissue graft will not reject
the graft. In humans, the MHC is called the HLA complex, which refers to "h__n
l___e a____s." Histocompatibility is a relationship of d___r and host based upon
the presence of compatible HLA a____s.
The histocompatibility-linked Ir genes play an important role but compose only a
p___t of the immune system. Certain Ir genes may code for c___r receptors for
antigen and others may control mediator s____n. The system controls not only
have the ability to r___d to antigens but also to control the l___l and d____n of the
The HLA complex is a region on chromosome _ that codes for three functionally
different proteins: those that r___late the immune response, those that determine
the a____ce or r___tion of transplanted tissues between individuals within that
species, and those that are a part of the c____ment system (Figure 4-1). The
MHC of m___e has provided information for the understanding of the human