Class
(WHO nomenclature,
lgG
lgA
lgM
lgD
lgE
(1964)
G
A
M
D
E
2A
1M, 2A
Old nomenclature
2 SS, 7S-
A1
19S
Structure
H-chain, class
4
2
2
2?
?
Number subclasses
L-chain, types
150,000
180,000 -
900,000
180,000
200,000
Molecular weight
500,000
Electrophorectic
slow
between
between
fast
mobility
Sedimentation
constant
6.7
7-15
19
7
8
S
20W
Carbohydrate
2.6
5-10
9.8
10 - 12
11
percentage
Gm allotypes (H-
+
0
0
0
0
chain)
Inv allotypes (L-chain)
+
+
?
?
?
Concentration, mg per
1,000-1500
200-350
85-205
3.0
0.01-
100 ml
0.07
Secretion
0
+
0
0
0
Antibody activity
Yes
Yes
Yes
?
Yes
reagent
Serologic
Usually
Usually
Usually
?
?
characteristics
incomplete
complete
complete
Fix complement
Yes
No
Yes
Yes
Yes
Crosses placenta
Yes
No
No
No
No
Table 1-1. Human Immunoglobulins.
MD0846
1-11