studies of hemoglobin, and bilirubin should be obtained. Several vials of RhIG can be
pooled in one syringe for a single injection. Not more than 5 ml should be injected at
one time into each buttock. If more than ten doses are required, the injections should
be spaced over the 72-hour period; however, the optimum time sequence for these
injections has not been established. Failure of this method to prevent Rh
alloimmunization usually means that the massive fetomaternal hemorrhage was
2-22. MATERNAL ALLOIMMUNIZATION TO PLATELETS, NEUTROPHILS, AND
PROTEIN ALL O TYPES
a. Neonatal thrombocytopenic purpose is an infrequent transient condition that
occurs by a mechanism analogous to the fetal RBC destruction in HDN. It is usually
caused by the platelet IgG alloantibodies anti-P1A and ant -P1E2.
b. Leukocyte lgG alloantibodies are common in the serums of pregnant women,
but they rarely cause problems in the newborn.
c. Although maternal alloimmunization to fetal Gm factors has been
documented, no deleterious effects are evident in the fetus or newborn. Gm antibodies
are primarily in the lgM class and, thus, would not cross the placenta.