(2) Irreversible cholinesterase inhibitors. These agents form a stable
complex with acetylcholinesterase.
(a) Echothiophate Iodide (Phospholine Iodide). Echothiophate iodide
is an irreversible indirect acting acetylcholinesterase inhibitor. It is used in the treatment
of glaucoma. The side effects associated with echothiophate include loss of bladder
control, muscle weakness, and shortness of breath. You should note that this
medication is supplied as a dry powder with diluent. The diluent and the dry powder
must be mixed just before you dispense it. The shelf life of the prepared solution can be
extended by refrigeration. Since echothiophate may cause changes in the patient's
vision, the patient should be warned to insure his vision is clear before he drives or
performs any job that requires him to have clear vision.
(b) Demecarium bromide (Humorsol). Demecarium bromide is an
irreversible, indirect acting acetylcholinesterase inhibitor. It is used in the treatment of
glaucoma. Side effects that can occur while taking this medication include loss of
bladder control, muscle weakness, and shortness of breath. Since this medication may
cause changes in the patient's vision, the patient should be warned to ensure his vision
is clear before he drives or performs any job which requires him to have clear vision.
MD0805
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