Quantcast
Section III. Antihyperlipidemics Agents - Pharmacology III

Share on Google+Share on FacebookShare on LinkedInShare on TwitterShare on DiggShare on Stumble Upon
Custom Search
 
  
 
mg per day in divided doses 1 to 4 times daily. Side effects include hypotension,
bradycardia, congestive heart failure (CHF), edema, and dermatitis.
Section III. ANTIHYPERLIPIDEMIC AGENTS
3-12. REVIEW OF ATHEROSCLEROSIS
Atherosclerosis is a condition in which lipid (fat) deposits form on the inside of the
arteries causing a decrease in the flow of blood through the arteries. The make up of
these deposits is mostly cholesterol as a consequence of genetic and dietary factors
which result in too much cholesterol. The arteries of most concern are the coronary
arteries (those that supply the heart) and the carotid arteries (those that supply the
brain). Hyperlipidemia is a condition of high levels of cholesterol, triglycerides, and /or
lipoprotein in the blood. The higher the levels in the blood, the greater the risk that they
will deposit on the inside of arteries. Several studies have shown a correlation between
cholesterol levels and premature heart disease. Studies have shown that each 1%
reduction in serum cholesterol correlates with a 2% decline in the risk of myocardial
infarction. For example, a 25% reduction in cholesterol will reduce the risk of
myocardial infarction by 50%. Diet, exercise, antihyperlipidemic drugs, and surgery are
the most common treatments. If a patient has high cholesterol only, and no evidence of
atherosclerosis, the treatment of the hyperlipidemia is referred to as primary prevention.
If the patient already has atherosclerosis, treatment is known as secondary prevention.
3-13. DEFINITIONS
a.  Cholesterol: A fat-related compound. It is a normal constituent of bile and a
principal constituent of gallstones. In body metabolism cholesterol is important as a
precursor of various steroid hormones such as sex hormones and adrenal corticoids.
Cholesterol is synthesized by the liver. It is widely distributed in nature, especially in
animal tissue such as glandular meats and egg yolk.
b.  Triglyceride (TG): A compound of three fatty acids esterified to glycerol. A
neutral fat, synthesized from carbohydrate, stored in adipose tissue. It releases free
fatty acids into the blood on being hydrolyzed by enzymes.
c.
Lipoproteins: Fat with protein. Major carrier of lipids in the plasma.
(1) Chylomicron: Particle of fat - lipoproteins - appearing in the lymph and
blood after a meal rich in fat. These particles are composed largely of triglycerides with
lesser amounts of phospholipids, cholesterol, esters, and protein. About 2 to 3 hours
after a fat meal, the chylomicrons cause lactescene (milkiness) in the blood plasma; this
is termed alimentary lipemia.
MD0806
3-8



Medical News
Death rates from pancreatic cancer predicted to rise in Europe in 2014
Pancreatic cancer is the only cancer for which deaths are...
medicalxpress.com
Genetics explain why some boys and girls are bigger than others
The influence of genetic factors on differences between children's Body...
medicalxpress.com
Bioethicists use theatrical narratives to bridge the gap between society and science
A pair of bioethics experts have added "playwright" to their...
medicalxpress.com
The best toxicology lab: a mouse with a human liver
A few years ago, Stanford pharmacogenomic expert Gary Peltz, MD,...
scopeblog.stanford.edu
How Great the Breast Ca Risk After Radiation as Child?
(MedPage Today) -- Women who survived childhood cancers treated with...
medpagetoday.com
Income Tax Fraud Appears to Target Docs
(MedPage Today) -- Hundreds of doctors across several states and...
medpagetoday.com
Stem cells in circulating blood affect cardiovascular health, study finds
New research suggests that attempts to isolate an elusive adult...
medicalxpress.com
Rural microbes could boost city dwellers' health
The greater prevalence of asthma, allergies and other chronic inflammatory...
medicalxpress.com
FDA Considers Ban on 'Aversive' Shock Devices
(MedPage Today) -- An FDA advisory committee will consider on...
medpagetoday.com
Big Data in Biomedicine technical showcase to feature companies’ innovations related to big data
In an effort to spark collaboration among thought leaders across...
scopeblog.stanford.edu
People with mild cognitive impairment may die at higher rate than people without condition
Mayo Clinic research studying the relationship between death and the...
medicalxpress.com
Marijuana use may increase heart complications in young, middle-aged adults
Marijuana use may result in cardiovascular-related complications—even death—among young and...
medicalxpress.com
People with more education may recover better from traumatic brain injury
People with more years of education may be better able...
medicalxpress.com
Iron consumption can increase risk for heart disease, study says
A new study from the Indiana University School of Public...
medicalxpress.com
Cyber buddy is better than 'no buddy'
A Michigan State University researcher is looking to give exercise...
medicalxpress.com
Study Suggests Heart Risk From Smoking Pot (CME/CE)
(MedPage Today) -- A French study provided support for an...
medpagetoday.com
Pollutants from coal-burning stoves strongly associated with miscarriages in Mongolia
Burning coal for domestic heating may contribute to early fetal...
medicalxpress.com
ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer
The American Society for Radiation Oncology (ASTRO) has issued a...
medicalxpress.com
MERS Watch: Saudi Numbers Up Again
(MedPage Today) -- Saudi Arabia is reporting 11 new cases...
medpagetoday.com
Review: sugar-sweetened drink intake tied to elevated BP
(HealthDay)—Sugar-sweetened beverage (SSB) intake is associated with elevated blood pressure...
medicalxpress.com
   


Privacy Statement - Copyright Information. - Contact Us

comments powered by Disqus

Integrated Publishing, Inc.
9438 US Hwy 19N #311 Port Richey, FL 34668

Phone For Parts Inquiries: (727) 755-3260
Google +