Quantcast Section III. Antihyperlipidemics Agents - Pharmacology III

Share on Google+Share on FacebookShare on LinkedInShare on TwitterShare on DiggShare on Stumble Upon
Custom Search
mg per day in divided doses 1 to 4 times daily. Side effects include hypotension,
bradycardia, congestive heart failure (CHF), edema, and dermatitis.
Atherosclerosis is a condition in which lipid (fat) deposits form on the inside of the
arteries causing a decrease in the flow of blood through the arteries. The make up of
these deposits is mostly cholesterol as a consequence of genetic and dietary factors
which result in too much cholesterol. The arteries of most concern are the coronary
arteries (those that supply the heart) and the carotid arteries (those that supply the
brain). Hyperlipidemia is a condition of high levels of cholesterol, triglycerides, and /or
lipoprotein in the blood. The higher the levels in the blood, the greater the risk that they
will deposit on the inside of arteries. Several studies have shown a correlation between
cholesterol levels and premature heart disease. Studies have shown that each 1%
reduction in serum cholesterol correlates with a 2% decline in the risk of myocardial
infarction. For example, a 25% reduction in cholesterol will reduce the risk of
myocardial infarction by 50%. Diet, exercise, antihyperlipidemic drugs, and surgery are
the most common treatments. If a patient has high cholesterol only, and no evidence of
atherosclerosis, the treatment of the hyperlipidemia is referred to as primary prevention.
If the patient already has atherosclerosis, treatment is known as secondary prevention.
a.  Cholesterol: A fat-related compound. It is a normal constituent of bile and a
principal constituent of gallstones. In body metabolism cholesterol is important as a
precursor of various steroid hormones such as sex hormones and adrenal corticoids.
Cholesterol is synthesized by the liver. It is widely distributed in nature, especially in
animal tissue such as glandular meats and egg yolk.
b.  Triglyceride (TG): A compound of three fatty acids esterified to glycerol. A
neutral fat, synthesized from carbohydrate, stored in adipose tissue. It releases free
fatty acids into the blood on being hydrolyzed by enzymes.
Lipoproteins: Fat with protein. Major carrier of lipids in the plasma.
(1) Chylomicron: Particle of fat - lipoproteins - appearing in the lymph and
blood after a meal rich in fat. These particles are composed largely of triglycerides with
lesser amounts of phospholipids, cholesterol, esters, and protein. About 2 to 3 hours
after a fat meal, the chylomicrons cause lactescene (milkiness) in the blood plasma; this
is termed alimentary lipemia.

Medical News
Serious adverse events rare in healthy volunteers participating in Phase I drug trials
Many people believe that phase I trials with healthy volunteers...
Predicting happiness of couples raising children with autism
Parenting can be stressful and parenting children with autism spectrum...
A key role for CEP63 in brain development and fertility discovered
Today in Nature Communications, scientists at the Institute for Research...
Mammography: Screening vs. Survival (CME/CE)
(MedPage Today) -- As more women are screened are more...
WHO needs urgent change to tackle health crises: experts
The World Health Organization (WHO) is institutionally unprepared to deal...
Cancer drug 49 times more potent than Cisplatin
Tests have shown that a new cancer drug, FY26, is...
Culture Shock: Liberia Ebola Cases No Surprise
(MedPage Today) -- West African country still doesn't have the...
That neat and tidy map of tastes on the tongue you learned in school is all wrong
Everybody has seen the tongue map – that little diagram...
Morning Break: Rebuilding After Ebola, 'Cancerism,' Buffett's Billions
(MedPage Today) -- Health news and commentary from around the...
Researcher discusses a new study on correlations among medical problems
What can big data tell us about the predictability of...
Enriched blood cells preserve cognition in mice with features of Alzheimer's disease
Cedars-Sinai researchers have successfully tested two new methods for preserving...
Aspirin may delay growth of asbestos-related cancer
Aspirin may inhibit the growth of mesothelioma, an aggressive and...
World-first in showing clinical-quality Proton CT for treatment of cancer
An international team of researchers will for the first time...
We all age at a different speeds – and scientists have worked out how to calculate it
A study has confirmed what many of us have been...
Infecting healthy adults with hookworm is the next step toward eradicating the infection
When Anna Markowitz learned that George Washington University researchers were...
Protecting yourself from rare flesh-eating bacteria found on Florida's beaches
The Florida Health Department has warned residents and tourists of...
WHO says too few countries taxing tobacco products enough
Taxing cigarettes up to 75 percent of their retail price...
70% of South African nurses moonlight – study
Between 2009 and 2010, the South African government spent over...
Researcher disputes claim that humans can distinguish one trillion odors
An Arizona State University researcher is calling into question recent...
Study shows second severe allergic reaction can occur hours after first
Parents of kids with severe allergies know how scary a...

Privacy Statement - Copyright Information. - Contact Us

comments powered by Disqus

Integrated Publishing, Inc.
9438 US Hwy 19N #311 Port Richey, FL 34668

Phone For Parts Inquiries: (727) 755-3260
Google +