(3)
Cautions and warnings.
(a)
Do not overlap with other antidepressants or monoamine oxidase
inhibitors.
(b)
The drug may produce drowsiness.
(c)
The patient should not consume any alcohol while taking the drug.
NOTE: Other SSRIs include sertraline (Zoloft), paroxetine (Paxil), citalopram
(Celexa), and fluvoxamine (Luvox).
Imipramine Hydrochloride (Tofranil).
b.
(1) Uses. Imipramine is used to treat depression; however, it can
paradoxically aggravate the anxiety sometimes associated with depression. Imipramine
also produces an anticholinergic effect and is therefore approved by the Food and Drug
Administration (FDA) for the treatment of enuresis (bedwetting) in children.
(2)
Adverse effects. Imipramine may produce the following adverse
effects:
(a)
Cardiovascular effects (that is, orthostatic hypotension).
(b)
Central nervous system effects (for example, confusion and
anxiety).
(c)
Gastrointestinal effects (that is, nausea and vomiting).
(d)
Anticholinergic effects (for example, dry mouth and constipation).
(3)
Cautions and warnings.
(a) Abruptly taking the drug away from the patient after long-term
therapy may produce withdrawal symptoms.
(b)
The drug may produce drowsiness.
(c)
The patient should not consume any alcohol while taking the drug.
(d) The drug should be used with caution in patients with glaucoma or
urinary retention because of its anticholinergic effects.
MD0804
9-11