CBER: Center for Biologics Evaluation and Research, the branch of the FDA that
oversees blood manufacture and practices.
CCBC: Council of Community Blood Centers.
CGMP: Current Good Manufacturing Practices are the methods used in, and the
facilities or controls used for, the manufacture, processing, packing, or holding of a drug
(including, but not limited to, blood products) to ensure that such product meets the
requirements of the Food, Drug and Cosmetic (FD&C) Act as to safety; and that it has
the identity and strength, and meets the quality and purity characteristics that it purports
or is represented to possess.
Chagas Disease: Disease endemic in South and Central America, which is caused by
the protozoan parasite Trypanosoma cruzi.
Codabar: Bar code symbology currently in use to produce bar codes for blood product
Bar code symbology to be used with blood labels. Code 128 is replacing
CMV: Cytomegalovirus. One of a group of species-specific herpes viruses.
Collins Box: DOD shipping container. Will maintain temperatures of 1 to 10 C for 30
units of RBCs, packed with 14 pounds of wet ice, for 48-72 hours.
Compatibility Testing: All pretransfusion testing performed on a potential transfusion
recipient and the appropriate donor blood. This testing is an attempt to ensure that the
product will survive in the recipient and induce improvement in the patient's clinical
condition. The crossmatch is between recipient's serum and donor's cells.
Complement: A series of proteins in the circulation that, when sequentially activated,
causes disruption of cell membranes. Activation occurs via one of two pathways, and
once activated, the components are involved in a great number of immune defense
mechanisms including anaphylaxis, chemotaxis, and phagocytosis. Red cell antibodies
that activate complement may be capable of causing hemolysis.
Component Therapy: Transfusion of specific components for treating a patient rather
than whole blood. These components, such as red blood cells, platelets, and plasma,
are separable by physical means, such as centrifugation.
CONUS: Continental US.
Cord Cells: Fetal cells obtained from the umbilical cord at birth.