(1) Mechanisms of action. These diuretics act on different areas of the
nephron unit at the same time. Diuresis is enhanced. Electrolyte imbalance is reduced.
(2) Specific indications for combination type diuretics. Combination
diuretics can be used for patients with these conditions:
(a) Mild diuresis.
(b) Excessive potassium wasting.
(3) Contraindications for combination type diuretics. Do not use
combination diuretics for patients with these conditions:
Hyperkalemia. (elevated potassium level in the blood).
(b) Hypersensitivity to thiazides or potassium-sparing agents.
Combination type diuretics are generally not prescribed as initial therapy.
Water is one of man's primary needs. Without a sufficient supply, all of us would
soon perish. Likewise, excessive amounts of fluid in the body can be just as fatal. Out
total body water and electrolytes are maintained in a delicate balance, and it is essential
to exercise great care when administering diuretic agents. Indiscriminate use of these
agents can result in severe fluid and electrolyte imbalance, which can be fatal to the