Quantcast CPD and CPDA-1. - Immunohematology and Blood Banking I

Share on Google+Share on FacebookShare on LinkedInShare on TwitterShare on DiggShare on Stumble Upon
Custom Search
 
  
 
(5)  The auxiliary preservative solutions in the additive systems are not
approved for whole blood, plasma components, platelets, or for use in plasma-pheresis
procedures. The anticoagulant CP2D has been approved for the preparation of routine
blood components including single donor plasma, cryo-precipitated antihemophilic
factor, and platelet concentrate.
(6)  Certain measurable biochemical changes occur when blood is stored at
1C to 6C. These changes, some of which are reversible, are known as the "storage
lesion" of blood. These changes are tabulated for CPD and CPDA-1 stored blood in
table 1-2 and additive systems in Table 1-3. Except for oxygen-transporting discussed
below, these rarely have clinical significance because transfusion volumes are small
and the recipient's compensatory homeostatic mechanisms reverse these changes.
Even in massive transfusion, the adverse effects of the red cell storage lesion are
usually inconsequential unless the recipient is already severely compromised.
(7)  In red cell storage and preservation, it is important to maintain oxygen-
carrying and oxygen-releasing capacities of hemoglobin. The concentration of red cell
2,3-DPG influences the release of oxygen to the tissues. If 2,3-DPG levels are high,
more oxygen is released at a given PO2. Lower red cell levels of 2,3-DPG cause greater
affinity of hemoglobin for oxygen so that less oxygen is released at the same PO2.
(8)  Concentrations of 2,3-DPG are affected by pH. The initial pH of blood
collected in CPD and measured at the temperature of storage is approximately 7.4 to
7.5. As stored red blood cells metabolize glucose to lactate, hydrogen ions accumulate,
plasma pH falls, and 2,3-DPG declines. Table 1-2 tabulates these changes for CPD and
CPDA-1. During the second week of storage, the pH of CPD stored blood falls below
7.0. As pH drops, there is a fall in red cell 2,3-DPG. Concentrations of 2,3-DPG are
normal in CPD-stored blood for about 10 days. When blood is stored in CPDA-1, 2, 3-
DPG levels initially fall slightly more rapidly than in CPD, but near normal levels are
maintained for 12 to 14 days.
(9)  Following transfusion, stored red blood cells regenerate ATP and 2,3-
DPG, resuming normal energy metabolism and hemoglobin function as they circulate in
the recipient. It usually takes from 3 to 8 hours for severely depleted cells to regenerate
half of their 2,3-DPG levels and approximately 24 hours for complete restoration of 2,3-
DPG and normal hemoglobin function. In red cell storage, maintaining cell viability is
unclear. On theoretical grounds, recipients likely to be most affected by low 2,3-DPG
levels in transfused blood are those receiving massive quantities of stored blood in a
short time, and those particularly vulnerable to the effects of tissue hypoxia; examples
include newborns undergoing exchange transfusion, patients with small blood volume
who receive large volumes of blood, and patients undergoing coronary artery bypass
surgery. Such patients usually receive blood less than 7 to 10 days old.
MD0845
1-37



Medical News
Half of world's rural populations cannot access health care: UN
More than half the population of rural areas worldwide do...
medicalxpress.com
Mathematical model seeks functional cure for HIV
(Medical Xpress)—Individuals with the natural ability to control HIV infection...
medicalxpress.com
Prenatal stem cell treatment improves mobility issues caused by spina bifida
The lower-limb paralysis associated with spina bifida may be effectively...
medicalxpress.com
The advantages of multilingualism
'Multilingualism is not a problem, it's a gift.' So says...
medicalxpress.com
New study aimed at diminishing phantom pain suffered by amputees
A new clinical trial conducted by Emory Saint Joseph's Hospital...
medicalxpress.com
Family becomes first in Southwest to take part in ground-breaking DNA research
A six-year-old boy and his mum and dad today became...
medicalxpress.com
Chipotle: Transition to non-GMO ingredients complete
Chipotle says it has completed phasing out genetically modified ingredients...
medicalxpress.com
Gonorrhoea and syphilis in Norway in 2014
Reported cases of gonorrhea continue to increase in Norway, both...
medicalxpress.com
Video: Delivering critical medicines into the body by way of vitamin B12
Chemists in the College of Arts and Sciences know the...
medicalxpress.com
World's first genetically modified human embryo raises ethical concerns
It all started with a rumour. Then just six weeks...
medicalxpress.com
Saturated fatty acids might directly damage heart
Olive oil is universally considered a much healthier alternative to...
medicalxpress.com
Instant self-test HIV kit on sale in Britain
Britain's first legally-approved HIV self-testing kit went on sale online...
medicalxpress.com
Transgender people pass on health care to avoid social stigma
Discussing your sexual history with a doctor, or anyone for...
medicalxpress.com
The art of maintaining cognitive health as our brains age
Brains age, just like the rest of the body, even...
medicalxpress.com
More than a third of New Jersey teens who engage in indoor tanning do so frequently, study finds
More than a third of New Jersey high school students...
medicalxpress.com
Light therapy hope for sleep troubled teens
Flinders University sleep researchers are taking research conducted in Adelaide...
medicalxpress.com
Seeing the same doctor could affect time to cancer diagnosis
Whether or not patients see the same GP could affect...
medicalxpress.com
Bioengineer takes an evolutionary approach to viral drug delivery vehicles
What do Washington lobbyists and gene therapy have in common?...
medicalxpress.com
Project to track rising threat of Lyme disease
Vets across the UK are set to take part in...
medicalxpress.com
New technology could let women skip annual mammograms
Technology developing at The University of Texas at El Paso...
medicalxpress.com
 


Privacy Statement - Copyright Information. - Contact Us

comments powered by Disqus

Integrated Publishing, Inc.
9438 US Hwy 19N #311 Port Richey, FL 34668

Phone For Parts Inquiries: (727) 755-3260
Google +