Quantcast CPD and CPDA-1. - Immunohematology and Blood Banking I

Share on Google+Share on FacebookShare on LinkedInShare on TwitterShare on DiggShare on Stumble Upon
Custom Search
 
  
 
(5)  The auxiliary preservative solutions in the additive systems are not
approved for whole blood, plasma components, platelets, or for use in plasma-pheresis
procedures. The anticoagulant CP2D has been approved for the preparation of routine
blood components including single donor plasma, cryo-precipitated antihemophilic
factor, and platelet concentrate.
(6)  Certain measurable biochemical changes occur when blood is stored at
1C to 6C. These changes, some of which are reversible, are known as the "storage
lesion" of blood. These changes are tabulated for CPD and CPDA-1 stored blood in
table 1-2 and additive systems in Table 1-3. Except for oxygen-transporting discussed
below, these rarely have clinical significance because transfusion volumes are small
and the recipient's compensatory homeostatic mechanisms reverse these changes.
Even in massive transfusion, the adverse effects of the red cell storage lesion are
usually inconsequential unless the recipient is already severely compromised.
(7)  In red cell storage and preservation, it is important to maintain oxygen-
carrying and oxygen-releasing capacities of hemoglobin. The concentration of red cell
2,3-DPG influences the release of oxygen to the tissues. If 2,3-DPG levels are high,
more oxygen is released at a given PO2. Lower red cell levels of 2,3-DPG cause greater
affinity of hemoglobin for oxygen so that less oxygen is released at the same PO2.
(8)  Concentrations of 2,3-DPG are affected by pH. The initial pH of blood
collected in CPD and measured at the temperature of storage is approximately 7.4 to
7.5. As stored red blood cells metabolize glucose to lactate, hydrogen ions accumulate,
plasma pH falls, and 2,3-DPG declines. Table 1-2 tabulates these changes for CPD and
CPDA-1. During the second week of storage, the pH of CPD stored blood falls below
7.0. As pH drops, there is a fall in red cell 2,3-DPG. Concentrations of 2,3-DPG are
normal in CPD-stored blood for about 10 days. When blood is stored in CPDA-1, 2, 3-
DPG levels initially fall slightly more rapidly than in CPD, but near normal levels are
maintained for 12 to 14 days.
(9)  Following transfusion, stored red blood cells regenerate ATP and 2,3-
DPG, resuming normal energy metabolism and hemoglobin function as they circulate in
the recipient. It usually takes from 3 to 8 hours for severely depleted cells to regenerate
half of their 2,3-DPG levels and approximately 24 hours for complete restoration of 2,3-
DPG and normal hemoglobin function. In red cell storage, maintaining cell viability is
unclear. On theoretical grounds, recipients likely to be most affected by low 2,3-DPG
levels in transfused blood are those receiving massive quantities of stored blood in a
short time, and those particularly vulnerable to the effects of tissue hypoxia; examples
include newborns undergoing exchange transfusion, patients with small blood volume
who receive large volumes of blood, and patients undergoing coronary artery bypass
surgery. Such patients usually receive blood less than 7 to 10 days old.
MD0845
1-37



Medical News
FDA approves hard-to-abuse narcotic painkiller
(HealthDay)—A new formulation of a powerful narcotic painkiller that discourages...
medicalxpress.com
Is coffee aggravating your hot flashes?
(HealthDay)—Drinking caffeine may worsen the hot flashes and night sweats...
medicalxpress.com
Neymar's brain on auto-pilot - Japan neurologists
Brazilian superstar Neymar's brain activity while dancing past opponents is...
medicalxpress.com
Race affects opioid selection for cancer pain
(HealthDay)—Racial disparities exist in the type of opioid prescribed for...
medicalxpress.com
Patients give high marks to shared medical appointments
(HealthDay)—Shared medical appointments (SMAs) improve patient satisfaction with primary care,...
medicalxpress.com
Beatings and addiction: Pakistan drug 'clinic' prescribes torture
Hashish addict Noor Rehman has spent three years chained to...
medicalxpress.com
AAFP: family docs report potential misuse of MGMA data
(HealthDay)—Reports from family physicians have been received that employers may...
medicalxpress.com
Chicken off McDonald's HK menu after food scandal
(AP)—McDonald's restaurants in Hong Kong have taken chicken nuggets and...
medicalxpress.com
Maternal gestational weight tied to offspring's asthma risk
(HealthDay)—Maternal obesity in pregnancy (MOP) and high maternal gestational weight...
medicalxpress.com
Feds cap fines for not buying health insurance
(AP)—Federal officials have capped the amount of money scofflaws will...
medicalxpress.com
FDA approves tough-to-abuse formulation of oxycodone
(HealthDay)—Targiniq ER (oxycodone hydrochloride and naloxone hydrochloride extended release) has...
medicalxpress.com
Tough-to-abuse formulation of oxycodone approved
(HealthDay)—Targiniq ER (oxycodone hydrochloride and naloxone hydrochloride extended release) has...
medicalxpress.com
Teenage boys want intimacy, not just sex, survey finds
(HealthDay)—The stereotype of the sex-crazed teenage boy may be dead...
medicalxpress.com
Ob-gyn guidance issued for young cancer patient concerns
(HealthDay)—Young cancer patients and survivors may have gynecologic concerns, which...
medicalxpress.com
Informed consent: False positives not a worry in lung cancer study
The U.S. Preventive Services Task Force recently recommended computerized tomography...
medicalxpress.com
Less than 1 percent of UK public research funding spent on antibiotic research in past 5 years
Less than 1% of research funding awarded by public and...
medicalxpress.com
Smartphone experiment tracks whether our life story is written in our gut bacteria
Life events such as visiting another country or contracting a...
medicalxpress.com
Total darkness at night is key to success of breast cancer therapy
Exposure to light at night, which shuts off nighttime production...
medicalxpress.com
Monitoring the rise and fall of the microbiome
Trillions of bacteria live in each person's digestive tract. Scientists...
medicalxpress.com
Common blood thinner for pregnant women proven ineffective
It's a daily injection to the belly for pregnant women...
medicalxpress.com
 


Privacy Statement - Copyright Information. - Contact Us

comments powered by Disqus

Integrated Publishing, Inc.
9438 US Hwy 19N #311 Port Richey, FL 34668

Phone For Parts Inquiries: (727) 755-3260
Google +