Thioridazine Hydrochloride (Mellaril).
(1) Use. This is a phenothiazine used to treat acute and chronic types of
psychosis. Thioridazine is safe in treating psychotic patients who also have liver
Adverse effects. Thioridazine produces the following adverse effects:
Sedation and lethargy.
Uses. Perphenazine is used in the management of psychotic disorders.
(2) Adverse effects. Perphenazine, like chlorpromazine, can produce
extrapyramidal reactions, orthostatic hypotension, drowsiness, and dry mouth
(drowsiness and orthostatic hypotension are less than that seen with chlorpromazine).
(3) Cautions and warnings. Perphenazine may cause drowsiness.
Patients should avoid alcohol and other CNS depressants while taking this drug.
Trifluoperazine Hydrochloride (Stelazine).
(1) Use. This phenothiazine is used in the treatment of various types of
acute and chronic psychoses. This drug is used primarily in the maintenance treatment
of psychotic patients.
Adverse effects. Two adverse effects are produced by this drug:
Drowsiness may occur with the use of this drug.
Extrapyramidal reactions may occur with the use of this drug.
(3) Cautions and warnings. The following cautions and warnings are
associated with trifluoperazine:
(a) The use of alcohol with this agent should be avoided
because of the possible interaction between the two substances.
(b) Since the drug can produce sedation, the patient should be
cautioned against operating vehicles while under the effects of this drug.