d. Adverse Reactions. Agranulocytosis, aplastic anemia, stomatitis, nausea,
emesis, abdominal pains, headache, peripheral neuritis, erythema multiforme, Stevens-
Johnson syndrome, generalized skin eruptions, drug fever, and chills have been
e. Supply. Sulfadoxine and pyrimethamine (Fansidar) are supplied as scored
tablets containing 500 mg sulfadoxine and 25-mg pyrimethamine.
Section V. ANTHELMINTIC DRUGS
An anthelmintic is a drug used to counteract infections with worms or helminths.
There are two phyla (categories) of helminths--the nemathelminths (roundworms) and
the platyhelminths (flatworms, a phylum composed of flukes and tapeworms).
Roundworms are also called nematodes. Flukes are called trematodes. Tapeworms
are called cestodes.
6-27. DRUGS OF CHOICE FOR SPECIFIC INFECTIONS
Below is a list of different types of helminthic infections, followed in parentheses
by the common name of the infection, followed (after a dash) by the names of the drugs
of choice for treating that particular infection. Names of alternate drugs for treating an
infection are placed in parentheses.
a. Infections with Roundworms.
(1) Ascaris lumbricoides (giant intestinal roundworm)--paperazine,
mebendazole (or pyrantel pamoate).
(2) Ancylostoma duodenale (hookworm, Old World type)--mebendazole (or
Necator americanus (hookworm, tropical type)--mebendazole.
(4) Strongyloides stercoralis (threadworm)--thiabendazole (or perhaps
Enterobius vermicularis (pinworm)--pyrantel pamoate (or mebendazole).
Trichuris trichiura (whipworm)--mebendazole.