(2) Pinworms can be treated with 65 mg/kg daily for 7-8 consecutive days
(maximum daily dose = 2.5-grams).
c. Cautions and Warnings.
(1) It has been reported that clients with a predisposition to grand mal or
petit mal have been reported to have an exacerbation of seizures following
administration of piperazine.
Piperazine may be used during the third trimester of pregnancy.
d. Adverse Reactions. Mild adverse reactions include nausea, vomiting, mild
diarrhea, abdominal pain, and headache.
e. Supply. Each 5-ml of piperazine citrate syrup, as available in supply
channels, contains the equivalent of 0.5-gram of piperazine hexahydrate.
a. Indications. Niclosamide inhibits oxidative phosphorylation in cestodes. The
scolex and segments are killed on contact with the drug. It is effective in the treatment
of Taenia saginata (beef tapeworm), Diphyllobothrium latum (fish tapeworm), and
Hymenolepis nana (dwarf tapeworm).
b. Usual dosage. Tablets should be thoroughly chewed, then swallowed with a
small amount of water. No special dietary restrictions are required although
niclosamide should be taken after a light meal. Segments of the ova may be present in
the stool for up to 3 days following treatment. A second course of therapy should be
administered if ova are still present after 7 days following therapy. A client is not cured
unless the stool has been negative for a minimum of 3 months.
T. saginata and D. latum (beef and fish tapeworm)
4 tablets (2 grams) in a single dose
3 tablets in a single dose
25 to < 75-lbs 2 tablets in a single dose
Hymenolepis nana (dwarf tapeworm)
4 tablets as a single daily dose for 7 days
3 tablets on 1st day, then 2 tablets
daily for the next 6 days
25 to 75-lbs 2 tablets on 1st day followed by
1 tablet daily for the next 6 days.