(2) Younger children: Make a suspension of two CP tablets in 75-ml
of water so that each 5-ml equals 40-mg of chloroquine base and 6-mg of
primaquine base.
Children's weekly dose: 10-15 pounds
=
1/2 tsp
16-25 pounds
=
1 tsp
26-35 pounds
=
1 1/2 tsp
36-45 pounds
=
2 tsp
46-55 pounds
=
2 1/2 tsp
56-100 pounds
=
1/2 tablet
c. Adverse Effects. Occasionally, CP tablets produce intestinal cramps and
loose stools. Serious hematologic effects have been reported with G6PD deficiency.
Diarrhea can be handled by breaking up tablets, taking with meals or cheese, or
combating with Lomotil if other measures fail.
d. Cautions and Warnings.
(1)
The CP tablet should not be used in the treatment of malaria.
(2) Some individuals may respond to the primaquine in the CP tablet with a
hemolytic reaction. If this happens and is severe enough, plain chloroquine tablets at
the same dosage may be substituted for prophylaxis.
(3) Concurrent use of quinacrine with primaquine may cause
agranulocytosis.
(4) Dapsone, 25-mg daily, may be used as an adjunct to the CP tablet in
resistant falciparum areas.
6-20. CHLOROQUINE
a. Indications. Chloroquine (Aralen) is a blood schizonticide indicated in the:
(1)
Treatment of uncomplicated attacks of malaria except resistant P.
falciparum.
(2)
Parenteral treatment of severe malaria illness except resistant P.
falciparum.
(3)
Prophylaxis and suppression of malaria while in an endemic area.
NOTE:
This drug is also indicated for treatment of discoid lupus erythematosis,
rheumatoid arthritis, and extraintestinal amebiasis.
MD0913
6-19