4-32. CHLORPHENIRAMINE MALEATE
a. Uses. Chlorpheniramine maleate is an effective antihistamine with a low
incidence of side effects. It is available under many trade names, including Allerest,
Chlor-Trimeton, Coricidin, Extendryl, Novahistine, and Teldrin.
b. Administration. The usual dose is 2-4 mg, 3 or 4 times daily. The usual
parenteral dose is 10-20 mg.
c. How Supplied. Chlorpheniramine maleate is an ingredient of numerous
preparations intended for the common cold, sinusitis, and allergic rhinitis. In addition, it
is available as the sole ingredient in a syrup (2-mg/5 ml), 4-mg tablets, and 8-mg timed-
4-33. TRIPROLIDINE HYDROCHLORIDE
a. Uses. Triprolidine hydrochloride (Actidil) is an unusually potent
antihistamine with a rapid onset of action. The maximum effect occurs in about 3 1/2
hours, and the effect lasts for about 12 hours.
b. Administration. The usual oral dose is 2.5-mg, 2 or 3 times daily.
c. How Supplied. Triprolidine hydrochloride is supplied in combination with
pseudoepinephrine hydrochloride, a sympathomimetic drug included as a
decongestant. Actifed is a common trade name for the mixture, available as a syrup
(1.25-mg of triprolidine HC1 and 30-mg of pseudoepinephrine HC1 per 5 ml) and a
tablet (2.5-mg of triprolidine HC1 and 60-mg of pseudoepinephrine HC1 per tablet).
Section VII. OTHER AGENTS
4-34. HYDROCORTISONE SODIUM SUCCINATE
a. Action and Uses. Except for its use in adrenal insufficiency, treatment with
hydrocortisone sodium succinate (Solu-Cortef*) (HC) is only palliative. Hydrocortisone
sodium succinate is used primarily for its anti-inflammatory effects. It is used in the
large single dose described below for some severe life-threatening situations, including
severe asthmatic or anaphylactic reactions, acute adrenal cortical insufficiency, and
b. Administration. This drug is given either intramuscularly or intravenously.
For the treatment of emergency conditions, the usual dose is 100 mg given over a
period of 60 seconds. The symptoms of stress are usually gone about 10 hours from
the time of administration of the drug. However, the client may suffer a relapse if the