DRUGS USED TO PREVENT AND TREAT INFECTION II
Section I. AMINOGLYCOSIDES
The aminoglycosides, a group of antibiotics including streptomycin, neomycin,
gentamicin, and kanamycin, are similar in mode of antimicrobial action, toxic effects,
pharmacology, and chemistry.
a. Indications. Streptomycin is a narrow-spectrum antibiotic used for the
Yersinis pestis (bubonic plague).
Francisella tularensis (tularemia).
Other organisms of known sensitivity.
b. Usual Dosage.
For tuberculosis--1 gram, given once daily, usually in combination with
For tularemia--1 to 2 grams daily in divided doses for 7 to 10 days.
For plague--2 to 4 grams daily in divided doses.
(4) For severe fulminating infections caused by known sensitive organisms,
usually in combination with other antibiotics.
(a) Adult--2 to 4 grams daily, given in divided doses every 6 to 12
(b) Child--20 to 40 mg/kg of body weight, in divided doses every 6 to
This drug is given intramuscularly only.