(2) Praziquantel appears in breast milk. Women should not nurse on the
day of treatment and during the subsequent 72 hours.
Safety and efficacy in children under 4 years of age have not been
d. Adverse Reactions. Praziquantel is well tolerated and side effects are
usually mild. The most frequently reported side effects are malaise, headache,
dizziness, and abdominal discomfort.
e. Supply. Praziquantel (Biltricide) is supplied as 600 mg film-coated tablets.
Section VI. OTHER AGENTS
a. Indications. Metronidazole (Flagyl) is indicated in protozoal infections
caused by the following organisms:
Trichomonas vaginalis in both males and females.
Entamoeba histolytica (a species of amebas).
b. Usual Dosage.
Trichomoniasis--concurrent treatment of sexual partners:
(a) Female--one tablet three times a day for 10 days.
(b) Male--one tablet twice a day for 10 days.
(2) Giardiasis--two courses of metronidazole therapy: 500-mg daily for 5
days, repeated after a 15-day interval.
(3) Amebiasis (infection with amebas, especially E. histolytica, both
intestinal infections and hepatic abscesses: 750-mg three times a day for 5 to 10 days.
c. Adverse Reactions. There is a low incidence of untoward effects. Nausea,
vomiting, a metallic taste, and a darkening of the urine are the most commonly reported