c. Benzathine Penicillin G, Procaine Penicillin G, and Potassium Penicillin
G for Injection. This is a dry powder form that must be reconstituted. It contains
600,000 units of benzathine penicillin G, 300,000 units of potassium penicillin G, and
300,000 units of procaine penicillin G.
5-17. POTASSIUM PHENOXYMETHYL PENICILLIN (PENICILLIN V)
(1) Penicillin V is the phenoxymethyl analog of penicillin G. It has the same
basic activity as penicillin G and is intended for oral use only. Penicillin V is not active
against the penicillinase-producing bacteria. Penicillin V has the distinct advantage
over penicillin G in resistance to inactivation by gastric acid and that it may be given
(2) Penicillin V is indicated for the treatment of mild to moderately severe
infections due to penicillin G-sensitive microorganisms that are sensitive to the low
serum levels common to this particular dosage form.
NOTE: Therapy should be guided by bacteriological studies and by clinical response.
Severe pneumonia, empyema, bacteremia, pericarditis, meningitis, and arthritis
should not be treated with penicillin V during the acute stage.
b. Usual Dosage.
(1) The dosage of penicillin V should be determined according to the
sensitivity of the causative microorganism, the severity of the infection, and adjusted to
the client's clinical response.
(2) The usual dose range for adults and children who are 12 years of age
and older is 200,000 to 500,000 units every 6 to 8 hours.
c. Cautions and Warnings.
A previous hypersensitivity reaction to any penicillin is a contraindication.
(2) Hypersensitivity reactions are more likely to occur in clients with a
history of sensitivity to multiple allergens or asthma.
(3) The oral route of administration should not be relied on in clients with
severe illness or with nausea, vomiting, gastric dilatation, cardiospasm or intestinal
(4) Therapy must be maintained for at least 10 days in streptococcal
infections to completely eliminate the organism.