Prophylaxis against bacterial endocarditis.
NOTE: In the above infections when high sustained serum levels are required,
potassium penicillin G for injection should be used.
b. Usual Dosage. This preparation is given IM only. The usual recommended
dose is 600,000 to 2,400,000 units daily according to the susceptibility of the organism
and the severity of the infection. For the treatment of gonorrhea, the usual doses are as
Males--2.4 million to 4.8 million units in one-day treatment.
Females--4.8 million units in one-day treatment.
(3) Probenecid (1 gram orally) should be used to potentiate the action of
procaine penicillin G in gonorrhea.
c. Cautions and Warnings.
A previous hypersensitivity reaction to any penicillin is a contraindication.
Avoid accidental intravenous administration.
Use with caution in individuals with histories of significant allergies or
(4) In suspected staphylococcal infections, proper laboratory studies,
including sensitivity tests, should be performed.
The use of antibiotics may result in overgrowth of nonsusceptible
(6) Periodic evaluation of renal and hematopoietic systems are
recommended in prolonged therapy with penicillin, particularly with high dosage
(7) Monthly serological tests should be made for at least four months when
treating gonococcal infections in which primary or secondary syphilis may be suspected.