e. Treatment of Overdosage.
(1) Lavage, if drug has been orally ingested, and sedate with a barbiturate
or diazepam (Valium).
Maintain a high volume of acid urine.
Use saline cathartic if the drug has been orally ingested.
Give artificial respiration if cyanosis is present.
Maintain blood pressure with fluids in the presence of cardiovascular
Administer as an alternative chlorpromazine (Thorazine), 1 mg/kg IM for
f. Cautions and Warnings.
(1) Amphetamines are contraindicated in advanced arteriosclerosis,
symptomatic cardiovascular disease, moderate to severe hypertension,
hyperthyroidism, and known hypersensitivity or idiosyncracy to the sympathomimetic
Do not administer to clients with a history of drug abuse.
Do not use during or within 14 days following the administration of MAO
(4) Tolerance to anorectic (appetite-reducing) effect usually develops within
a few weeks.
(5) Amphetamines may impair the ability of the client to engage in
potentially hazardous activities.
Tolerance and extreme psychological dependence have occurred.
(7) Abrupt cessation following prolonged high dosage results in extreme
fatigue and mental depression.
(8) Manifestations of chronic intoxication include severe skin diseases,
marked insomnia, irritability, hyperactivity, and personality changes, including psychosis
often clinically indistinguishable from schizophrenia.