Quantcast Factors Affecting Drug Action - Drug Dosage and Theraphy

Share on Google+Share on FacebookShare on LinkedInShare on TwitterShare on DiggShare on Stumble Upon
Custom Search
 
  
 
a. The average dose, also called the usual dose, is the amount of drug that
ordinarily produces the effect for which the drug is intended. In addition to the usual
dose, the usual dose range is often indicated for many drugs in standard pharmacy
references. This provides a guide to dispensing personnel in deciding whether the
prescriber should be consulted about the correctness of a prescribed dose. The usual
dose range is the range of doses that consistently produce the effect for which the drug
is intended.
b. The minimum dose is the smallest dose that produces a therapeutic effect.
c. The maximum dose is the largest dose that can be safely administered.
d. The toxic dose is the dose that produces harmful effects.
e. The lethal dose is the dose that will result in death. The minimum lethal dose
(MLD) is the smallest amount that will cause death.
f. The single dose is the amount of a drug taken at one time. The daily dose is
the total amount of a drug taken in 24 hours. A continuous dose consists of small doses
taken at short intervals. A maintenance dose is that amount of drug taken to replace
previous doses that have been inactivated, detoxified, or excreted. The purpose of a
maintenance dose is to maintain the required concentration of the drug in the body.
2-4.
FACTORS AFFECTING DRUG ACTION
In drug administration, many factors affect the action of the medication. These
factors also affect the dose to be administered. The usual adult dose of medication as
listed in standard references, is based on the assumption that the adult weighs 150
pounds, but since the following variables influence the action of the medication, they
also may alter the quantity of the drug necessary to produce the desired results.
a. Weight. Heavy, burly clients require larger doses than weak, emaciated
ones. The doses of many drugs are calculated on a weight basis; a specified number of
grams or milligrams are administered per pound or kilogram of body weight.
b. Age. As a rule, the very young and the very old require less than the normal
adult dose. As you recall from lesson 1, several formulas are available for estimating a
child's dose when the average adult dose is known.
c. Sex. Females usually require smaller doses than males. Iron preparations
and other hematinics are exceptions to this rule because of the blood lost by women
during menstruation.
d. Race. Race can be a factor affecting drug action, since enzyme systems,
body chemistry, and stature may vary.
MD0913
2-5



Medical News
Sweden discovers suspected case of Ebola, official reports
A suspected case of the Ebola virus has been discovered...
medicalxpress.com
Novartis Japan admits concealing drug side effects
The Japanese unit of Swiss pharma giant Novartis has admitted...
medicalxpress.com
19 new dengue cases in Japan, linked to Tokyo park
Japan is urging local authorities to be on the lookout...
medicalxpress.com
Sugar substance 'kills' good HDL cholesterol, new study finds
Scientists at the University of Warwick have discovered that 'good'...
medicalxpress.com
Doctor revalidation needs to address seven key issues for success, claims report
New research launched today, September 1, 2014, has concluded that...
medicalxpress.com
US judge blocks enforcement of new abortion law
A federal judge has temporarily blocked Louisiana from enforcing its...
medicalxpress.com
ESC: No Pre-PCI Boost from Brilinta in Ambulance (CME/CE)
BARCELONA (MedPage Today) -- Giving the antiplatelet drug ticagrelor (Brilinta)...
medpagetoday.com
ESC: Ultrathin Stent Proves Mettle in Post-PCI Patients (CME/CE)
BARCELONA (MedPage Today) -- An ultrathin biodegradable sirolimus-eluting stent (Orsiro)...
medpagetoday.com
New tuberculosis blood test in children is reliable and highly specific
A new blood test provides a fast and accurate tool...
medicalxpress.com
Invisible blood in urine may indicate bladder cancer
New research which finds that invisible blood in urine may...
medicalxpress.com
The Week Ahead: ESC, ICAAC, ERS, and FDA on Sunscreen
(MedPage Today) -- It's a big week for meetings: MedPage...
medpagetoday.com
Colombian president: No link of vaccine to illness
Colombia's president is dismissing suggestions that a vaccine against cervical...
medicalxpress.com
Health workers death toll mounts in W.Africa as Ebola spreads
Nigeria on Sunday confirmed a fresh case of Ebola in...
medicalxpress.com
Estrogen May Be Key to Anti-Binge Tx (CME/CE)
(MedPage Today) -- Researchers have identified a receptor that mediates...
medpagetoday.com
Gene clues to glaucoma risk
Scientists on Sunday said they had identified six genetic variants...
medicalxpress.com
Memory in silent neurons
According to a generally-accepted model of synaptic plasticity, a neuron...
medicalxpress.com
Memory and Alzheimer's: Towards a better comprehension of the dynamic mechanisms
A study just published in the prestigious Nature Neuroscience journal...
medicalxpress.com
A new way to diagnose malaria, using magnetic fields
Over the past several decades, malaria diagnosis has changed very...
medicalxpress.com
ESC: Evidence Mounts for Injection to Lower LDL-C (CME/CE)
BARCELONA (MedPage Today) -- Four studies testing the injectable novel...
medpagetoday.com
Facts, Myths, and the Stool DNA Test
(MedPage Today) -- Publicity surrounding the FDA's approval of a...
medpagetoday.com
 


Privacy Statement - Copyright Information. - Contact Us

comments powered by Disqus

Integrated Publishing, Inc.
9438 US Hwy 19N #311 Port Richey, FL 34668

Phone For Parts Inquiries: (727) 755-3260
Google +