Quantcast Factors Affecting Drug Action - Drug Dosage and Theraphy

Share on Google+Share on FacebookShare on LinkedInShare on TwitterShare on DiggShare on Stumble Upon
Custom Search
 
  
 
a. The average dose, also called the usual dose, is the amount of drug that
ordinarily produces the effect for which the drug is intended. In addition to the usual
dose, the usual dose range is often indicated for many drugs in standard pharmacy
references. This provides a guide to dispensing personnel in deciding whether the
prescriber should be consulted about the correctness of a prescribed dose. The usual
dose range is the range of doses that consistently produce the effect for which the drug
is intended.
b. The minimum dose is the smallest dose that produces a therapeutic effect.
c. The maximum dose is the largest dose that can be safely administered.
d. The toxic dose is the dose that produces harmful effects.
e. The lethal dose is the dose that will result in death. The minimum lethal dose
(MLD) is the smallest amount that will cause death.
f. The single dose is the amount of a drug taken at one time. The daily dose is
the total amount of a drug taken in 24 hours. A continuous dose consists of small doses
taken at short intervals. A maintenance dose is that amount of drug taken to replace
previous doses that have been inactivated, detoxified, or excreted. The purpose of a
maintenance dose is to maintain the required concentration of the drug in the body.
2-4.
FACTORS AFFECTING DRUG ACTION
In drug administration, many factors affect the action of the medication. These
factors also affect the dose to be administered. The usual adult dose of medication as
listed in standard references, is based on the assumption that the adult weighs 150
pounds, but since the following variables influence the action of the medication, they
also may alter the quantity of the drug necessary to produce the desired results.
a. Weight. Heavy, burly clients require larger doses than weak, emaciated
ones. The doses of many drugs are calculated on a weight basis; a specified number of
grams or milligrams are administered per pound or kilogram of body weight.
b. Age. As a rule, the very young and the very old require less than the normal
adult dose. As you recall from lesson 1, several formulas are available for estimating a
child's dose when the average adult dose is known.
c. Sex. Females usually require smaller doses than males. Iron preparations
and other hematinics are exceptions to this rule because of the blood lost by women
during menstruation.
d. Race. Race can be a factor affecting drug action, since enzyme systems,
body chemistry, and stature may vary.
MD0913
2-5



Medical News
Doctors urge meningitis shots for vulnerable infants, children
(HealthDay)—Infants and children who are at risk of contracting meningitis...
medicalxpress.com
Preemies may have higher risk of blood clots, even as adults
(HealthDay)—Babies born prematurely appear to have a slightly increased risk...
medicalxpress.com
Tonsillectomy for sleep apnea may trigger weight gain
(HealthDay)—Tonsillectomies are commonly done to relieve sleep apnea in children,...
medicalxpress.com
A closer look at new research showing disproportionate rates of melanoma in Marin County
Last week, Cancer Prevention Institute of California/Stanford Cancer Institute researcher...
scopeblog.stanford.edu
Early hormone therapy may be safe for women's hearts
(HealthDay)—Healthy women at low risk of cardiovascular disease may be...
medicalxpress.com
Type of lymphoma treatment impacts degree of harm to sperm
(HealthDay)—Lymphoma treatment has damaging effects on spermatogenesis but, in most...
medicalxpress.com
AAP updates recommendations for meningococcal vaccines
(HealthDay)—New recommendations are presented for meningococcal vaccination in a policy...
medicalxpress.com
Do Decision Aids Help Patients Make Difficult Choices? (CME/CE)
(MedPage Today) -- Decision aids designed to help patients make...
medpagetoday.com
Human brain has coping mechanism for dehydration
(HealthDay)—Although dehydration significantly reduces blood flow to the brain, researchers...
medicalxpress.com
Low yield for repeat colonoscopy in some patients
(HealthDay)—Repeat colonoscopies within 10 years are of little benefit to...
medicalxpress.com
Teen vaccinations up but HPV coverage remains low overall
(HealthDay)—From 2012 to 2013, coverage for adolescents aged 13 to...
medicalxpress.com
Non-endoscopic migraine surgery provides significant symptom relief
A revised version of a surgical procedure to treat severe...
medicalxpress.com
Electronic screening tool to triage teenagers and risk of substance misuse
An electronic screening tool that starts with a single question...
medicalxpress.com
Healthy school lunches get thumbs up from students
(HealthDay)—Elementary school students seem to be satisfied with the healthier...
medicalxpress.com
Research letter examines pacemaker use in patients with cognitive impairment
Dr. Nicole R. Fowler and her fellow reserachers have found...
medicalxpress.com
Dementia patients more likely to get implanted pacemakers, study says
People with dementia are more likely to get implanted pacemakers...
medicalxpress.com
Scientists discover genetic switch that can prevent peripheral vascular disease in mice
Millions of people in the United States have a circulatory...
medicalxpress.com
Forced mutations doom HIV: New study reveals how a potential HIV drug exacts its toll on viral populations
Fifteen years ago, MIT professor John Essigmann and colleagues from...
medicalxpress.com
Researchers capture detailed three-dimensional images of cardiac dynamics in zebrafish
The stunning video above depicts a reconstructed beating heart of...
scopeblog.stanford.edu
Glucose 'control switch' in the brain key to both types of diabetes
Researchers at Yale School of Medicine have pinpointed a mechanism...
medicalxpress.com
 


Privacy Statement - Copyright Information. - Contact Us

comments powered by Disqus

Integrated Publishing, Inc.
9438 US Hwy 19N #311 Port Richey, FL 34668

Phone For Parts Inquiries: (727) 755-3260
Google +