(1)
Examples of known effects:
(a) Physical abnormalities - no arms or legs.
(b) Hemorrhage or jaundice.
(c)
Neurologic symptoms.
(d) Abnormal dental pigmentation.
(e) Addiction.
(f)
Vaginal malignancy or altered sperm causing infertility.
(2) The effects of many drugs may not be known until later years during the
growth and development of the child.
c. Teratogenic drug examples.
(1)
Thalidomide-used in England in the 1950's and 1960's as a sedative.
(2)
Phenytoin (Dilantin)-used for seizures.
(3)
Methotrexate-used to treat neoplastic diseases.
(4)
Diethylstilbestrol-used for vasomotor symptoms during menopause.
(5)
Accutane--used to treat cystic acne.
d. Teratogenic viruses and parasites.
(1)
Herpes simplex.
(2)
Rubella (German measles).
(3)
Toxoplasmosis. This is transmitted by cat feces and raw meat.
(4)
Influenza or viral infections in the early weeks of pregnancy.
e. Other teratogenic conditions.
(1)
Hyperthermia.
(2)
Maternal disease (diabetes).
(3)
Maternal malnutrition.
MD0921
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