Metaproterenol (Alupent).
e.
(1) Pharmacological actions. Because of its specificity for beta2 receptors,
metaproterenol causes a relaxation of the bronchi and uterus--little effect upon the heart
is seen.
(2) Indication for the use of metaproterenol. Metaproterenol is used as a
bronchodilator for bronchial asthma. It improves pulmonary function for a period of from
1 to 5 hours.
(3)
Cautions and warnings associated with the use of metaproterenol:
(a) This drug is contraindicated with patients who have pre-existing
cardiac arrhythmias associated with tachycardia.
(b)
This drug is contraindicated in children under six years of age.
(4) Side effects associated with the use of this agent. Central nervous
system (CNS) stimulation and muscle tremors are commonly seen in-patients who take
Albuterol (Ventolin).
f.
(1) Pharmacological actions. This drug is specific for beta2 receptors and
causes relaxation of the bronchi and uterus. It has a longer duration of action than
metaproterenol
(2) Indications. Patients use albuterol as indicated for relief of broncho
spasm with reversible obstructive airway disease and prevention of exercise-induced
bronchospasm.
(3)
Cautions and warnings.
(a)
Safety and efficacy in children under age 12 have not been
established.
(b)
Use with caution in individuals with cardiovascular disorders.
(4) Side effects. Possible side effects associated with Albuterol include
CNS stimulation and palpitations.
Terbutaline (Brethine, Bricanyl).
g.
(1) Pharmacological actions. This drug is specific for beta2 receptors with
resultant relaxation of bronchial smooth muscle and uterus.
MD0805
7-8