(1) Size. The mature cell of this series varies greatly in size. Small
lymphocytes are 7 to 9 microns in diameter. The large lymphocytes are 10 to 18
microns in diameter.
(2) Nucleus. The nucleus is round or oval and can be slightly indented.
The nuclear chromatin is markedly condensed, dark purple-blue, and clumped. Nucleoli
are absent and a definite nuclear membrane ids present. The nucleus-cytoplasm ratio
is approximately 1.5:1.0.
(3) Cytoplasm. The cytoplasm is light blue to blue with a perinuclear clear
zone around the nucleus. A few azurophilic granules can be seen in the cytoplasm of
Figure 4-4c. Lymphocytic series:
The stages in the development of the monocytic series are monoblast,
promonocyte, and monocyte. Cells of the series are slightly larger than granulocytes.
They are round with smooth margins and seldom show shape variants. The mature
monocyte is differentiated from the lymphocyte and metamyelocyte by the very fine,
light staining nucleus.
Size. Twelve to 20 microns in diameter.
(2) Nucleus. The nucleus is round or oval and red-purple in color. The
nuclear chromatin is fine and well distributed. One to two nucleoli are present. The
nucleus-cytoplasm ratio is 6:1.
(3) Cytoplasm. The cytoplasm is a clear, deep blue and follow a thin rim
around the nucleus.