10.
If the results for the FANA are negative, the fluorescent intensity of the cells' nuclei
is about the same as that of the (negative) (positive) control, and there is no
discernible p____n in the nucleus.
If the results are positive, the fluorescent intensity of the cells' nuclei is
(less)(greater) than the negative control, and there is a clearly dis___ble pattern in
the nucleus. Report positive controls and patients by the specific fl____t pattern
observed.
11.
For a homogeneous pattern, there is sm__h, e__n staining of the nucleus. The
antibodies indicated are anti-native-D_ and anti-D_. The condition indicated by a
(high) (low) titer is SLE. The condition indicated by a (high) (low) titer is RA.
For a peripheral pattern, there is staining of the n___r m____e only. The antibody
indicated is anti-native-D_. The condition indicated is S_.
For a speckled pattern, there is g__y staining throughout the nucleus usually not
affecting the n___i. The antibodies indicated are anti-S_ and anti-R_. Four
possible conditions indicated are (RA) (SLE) (PSS) (SS) (MCTD).
For a nucleolar pattern, there is solid staining of the n____i. The antibodies
indicated are anti____r. The condition indicated is P_.
12.
The FANA is a laboratory diagnostic a__d and by itself is not d_____c. Positive
results require f____r testing for specific antinuclear antibody i_____cation and
quantitation.
Another limitation of the FANA is that SLE patients undergoing steroid therapy
may have (negative) (positive) test results. Also, many commonly prescribed
drugs may induce (negative) (positive) results.
Check Your Answers on Next Page
MD0838
6-13