c. Cautions and Warnings.
A diagnosis of a fungal infection should be supported by laboratory
Tolnaftate is of no use in Candida or bacterial infections.
It should not be applied to areas, which are acutely inflamed or infected.
(4) It may be of limited use in nail infections in conjunction with oral
antifungals. Nails should be trimmed to facilitate use of solution and prevent spread of
(5) It is less effective with hyperkeratotic lesions. Treat areas alternately
with 10 percent salicylic acid ointment and tolnaftate.
(6) It is useful in tinea versicolor, although relapses are common with all
types of therapy.
d. Adverse Effects. Adverse effects are relatively rare, although local irritation
characterized by erythema, pruritis, and a burning sensation may occur. In such cases,
the drug should be discontinued.
e. Supply. Tolnaftate solution is a nonaqueous 1 percent solution for
dermatological use only.
(1) Nystatin (Mycostatin; Nilstat) is indicated in the treatment of Candida
albicans (candidiasis, moniliasis, and thrush) infections of the skin, mucous
membranes, vagina, and gastrointestinal tract. This is often associated with prolonged
therapy with broad-spectrum antibiotics.
(2) Nystatin may be given with other antibiotics and may be indicated with
prolonged broad-spectrum antibiotics or steroid therapy to prevent superinfections.
b. Usual Dosage.
(a) Tablets--500,000 units to 1,000,000 units tid.
(b) Suspension--5 ml (500,000 units) swished in mouth and swallowed